Oxalyl chloride → 2-fluoro-N-methoxy-N,3-dimethylbenzamide

HRID 1294864ノート

反応式

HRID 1294864 の反応式
[F:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].Cl.[CH3:13][NH:14][O:15][CH3:16].C(Cl)(=O)C(Cl)=O>N1C=CC=CC=1>[F:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:14]([O:15][CH3:16])[CH3:13])=[O:5]

参加物

5

反応物 3

HCID 65578Oxalyl chlorideHCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 27373792-Fluoro-3-methylbenzoic acid

生成物 1

HCID 807180582-fluoro-N-methoxy-N,3-dimethylbenzamide収率 74.9%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Prepared according to Method A step A from 2-fluoro-3-methylbenzoic acid (5.0 g, 32.5 mmol), N,O-dimethylhydroxylamine hydrochloride (8.4 g, 87 mmol), oxalyl chloride (2.83 mL, 32.5 mmol) and 8 mL of pyridine to give the title compound (4.8 g) as an oil. Used as is in the next prep

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-61841e28ca6945818215ea0732a2e383
出典データセット
uspto-grants-2007_07
特許番号
US07241791B2

反応ノート

読み込み中…