Hydrazine hydrate (1:1) → HCID 178489139、化合物

HRID 1295038ノート

反応式

HRID 1295038 の反応式
[Cl:1][C:2]1[C:3](F)=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([F:18])[CH:11]=2)=O)[CH:5]=[CH:6][CH:7]=1.O.[NH2:21][NH2:22].CC1C=CN=C(N)C=1C>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:22][N:21]=[C:8]2[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([F:18])[CH:11]=1

参加物

5

反応物 3

HCID 24654Hydrazine hydrate (1:1)HCID 110078842-Amino-3,4-dimethylpyridineHCID 64712239(3-Chloro-2-fluorophenyl)(3-fluoro-4-methoxyphenyl)methanone

生成物 1

HCID 178489139HCID 178489139、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Prepared according to Method D, Step A from (3-chloro-2-fluorophenyl)(3-fluoro-4-methoxyphenyl)methanone (0.80 g, 2.83 mmol), hydrazine hydrate (1 mL), dimethyl-aminopyridine (0.390 g) and pyridine (5 mL). The reaction mixture was combined with a previous batch at this stage and the title compound was obtained as a white solid and recrystallized from ethyl acetate/hexane (1.30 g, 4.79 mmol, 83%).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-cd5d7a0041af4c7ea52ba0a95fa0f01d
出典データセット
uspto-grants-2007_07
特許番号
US07241791B2

反応ノート

読み込み中…