Sodium Hydroxide → HCID 58909200、化合物

HRID 1295613ノート

反応式

HRID 1295613 の反応式
[CH2:1]([NH:8][C:9]([C:11]1[CH:15]=[CH:14][O:13][C:12]=1[NH:16][C:17](=O)[CH2:18][CH2:19][CH3:20])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)CO>[CH2:1]([N:8]1[C:9](=[O:10])[C:11]2[CH:15]=[CH:14][O:13][C:12]=2[N:16]=[C:17]1[CH2:18][CH2:19][CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58909201HCID 58909201、化合物

生成物 1

HCID 58909200HCID 58909200、化合物

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

反応条件

温度
130 °C

実験手順

A mixture of N-benzyl-2-(butyrylamino)-3-furamide (1-2, 1 equiv) and sodium hydroxide (0.1 equiv) in ethylene glycol is heated at 130° C. for 5 h. The reaction mixture is allowed to cool, then partitioned between a half-saturated aqueous sodium chloride solution and ethyl acetate. The combined organic layers are dried over sodium sulfate and concentrated. The residue is purified by flash column (hexanes initially, grading to 100% ethyl acetate) to provide 3-benzyl-2-propylfuro[2,3-d]pyrimidin-4(3H)-one (1-3).

後処理

  1. temperatureto cool
  2. custompartitioned between a half-saturated aqueous sodium chloride solution and ethyl acetate
  3. dry with materialThe combined organic layers are dried over sodium sulfate
  4. concentrationconcentrated
  5. customThe residue is purified by flash column (hexanes initially

出典と根拠

ORDレコード
ord-26d96abbd1654d44b6d78cefdad46c82
出典データセット
uspto-grants-2007_07
特許番号
US07244723B2

反応ノート

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