Sodium Chloride → 4-(2,4,5-Trifluoro-phenoxy)butan-1-ol

HRID 1295718

反応式

HRID 1295718 の反応式
[CH2:1]([OH:6])[CH2:2][CH2:3][CH2:4][OH:5].CC([O-])(C)C.[K+].[F:13][C:14]1[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16][C:15]=1F.[Cl-].[Na+]>O.C1(C)C=CC=CC=1.CS(C)=O>[F:13][C:14]1[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16][C:15]=1[O:5][CH2:4][CH2:3][CH2:2][CH2:1][OH:6]

参加物

8

反応物 4

HCID 5234Sodium ChlorideHCID 80641,4-ButanediolHCID 94741,2,4,5-TetrafluorobenzeneHCID 23665647Potassium tert-butoxide

生成物 1

HCID 693646634-(2,4,5-Trifluoro-phenoxy)butan-1-ol

試薬・触媒・溶媒 3

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

To a mixture of 1,4-butanediol (15 g, 0.17 mol) and t-BuOK (8.0 g, 0.071 mol) were added 1,2,4,5-tetrafluorobenzene (5.0 g, 33 mmol) and DMSO (50 g) at 60° C. After being stirred at this temperature for 18 h, toluene (200 mL), water (50 mL) and sodium chloride (10 g) were added to the reaction mixture. The layers were separated and the organic layer was concentrated in vacuo giving the title compound. This material was used directly in the next step.

後処理

  1. customThe layers were separated
  2. concentrationthe organic layer was concentrated in vacuo

出典と根拠

ORDレコード
ord-663d6016ba36490f8673a3c4952bbb51
出典データセット
uspto-grants-2007_07
特許番号
US07244722B2

関連ノート

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