HCID 22929860、化合物 → HCID 22929965、化合物
反応式
[CH3:1][NH:2][C:3](=[O:19])[C:4]1[CH:9]=[C:8]([C:10]#[N:11])[C:7]([CH2:12][N:13]=[N+]=[N-])=[CH:6][C:5]=1[O:16][CH2:17][CH3:18]>O1CCCC1.N.C(P(CC)CC)C>[CH3:1][NH:2][C:3]([C:4]1[CH:9]=[C:8]2[C:7](=[CH:6][C:5]=1[O:16][CH2:17][CH3:18])[CH2:12][N:13]=[C:10]2[NH2:11])=[O:19]参加物
5
反応条件
- 温度
- 50 °C
実験手順
After dissolving N1-methyl-4-(azidomethyl)-5-cyano-2-ethoxybenzamide (931 mg) in tetrahydrofuran (10 ml), 28% aqueous ammonia (2 ml) and triethylphosphine (0.4 ml) were added in that order. The mixture was stirred at 50° C. for 15 minutes. The precipitated crystals were filtered off, washed with tetrahydrofuran, water and ethyl acetate in that order and dried to yield the title compound (365 mg).
後処理
- additionwere added in that order
- filtrationThe precipitated crystals were filtered off
- washwashed with tetrahydrofuran, water and ethyl acetate in that order
- customdried
出典と根拠
- ORDレコード
- ord-3e5ef1b9426a41e2ad7c3258811dfae9
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07244730B2
反応ノート
読み込み中…