N-bromobutanimide → 5-Bromo-3-fluoro-2-hydroxybenzaldehyde
反応式
[F:1][C:2]1[C:3]([OH:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[Br:11]N1C(=O)CCC1=O>C(#N)C.C(OCC)(=O)C>[Br:11][C:8]1[CH:9]=[C:2]([F:1])[C:3]([OH:10])=[C:4]([CH:7]=1)[CH:5]=[O:6]参加物
5
実験手順
596 mg of 3-fluoro-2-hydroxybenzaldehyde was dissolved in 5 ml of acetonitrile, and 770 mg of N-bromosuccinimide was added. The solution was stirred for 15 minutes at room temperature. The reaction mixture was diluted with ethyl acetate, and washed with water and saturated brine and dried over anhydrous magnesium sulfate. The solution was filtered and the solvent was evaporated, to give 928 mg of 5-bromo-3-fluoro-2-hydroxybenzaldehyde.
後処理
- washwashed with water and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationThe solution was filtered
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-ce3a698aac8640afbe3048ef15a0ed5c
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07244861B2
反応ノート
読み込み中…