1-Bromo-2-fluorobenzene → 5-(2-Fluorophenyl)-1-methylimidazole-4-carbonitrile

HRID 130027

反応式

HRID 130027 の反応式
Cn1cnc(C#N)c1.Fc1ccccc1Br>C=C[CH2-].C=C[CH2-].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].[Cl][Pd+].[Cl][Pd+].[Cs+].c1ccc(P(c2ccccc2)C2CCCCC2)cc1>Cn1cnc(C#N)c1-c1ccccc1F

参加物

9

反応物 2

HCID 612591-Bromo-2-fluorobenzeneHCID 27951151-Methyl-1H-imidazole-4-carbonitrile

生成物 2

HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 841174465-(2-Fluorophenyl)-1-methylimidazole-4-carbonitrile収率 37.54%

試薬・触媒・溶媒 5

HCID 583616Cesium pivalate試薬HCID 61538Palladium, di-mu-chlorobis(eta3-2-propenyl)di-触媒HCID 80756Phosphine, cyclohexyldiphenyl-触媒HCID 31374Dimethylacetamide溶媒HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl内部標準

反応条件

温度
120 °C

後処理

  1. additionThe plate was removed from the glovebox, opened, and diluted to a 900 uL total volume with N,N-dimethylacetamide. The plate was stirred for 5 min and a 75 uL sample was taken and filtered into an HPLC analysis plate. The filter was rinsed with 400 uL acetonitrile/water (4:1) solution and analyzed by UHPLCMS
  2. stirring手順は記録されていません
  3. aliquot手順は記録されていません
  4. filtrationorganic 相を保持

出典と根拠

ORDレコード
ord-028747c6a571457789fad4b0d96cec7b
出典データセット
Shields Arylation

関連ノート

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