3-(2,4-Difluorophenyl)acrylic Acid → 3-(2,4-difluorophenyl)propanoic Acid

HRID 130605

反応式

HRID 130605 の反応式
[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[H][H]>O1CCCC1.[Pd]>[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

参加物

5

反応物 2

HCID 6035023-(2,4-Difluorophenyl)acrylic AcidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 49863953-(2,4-difluorophenyl)propanoic Acid収率 98.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
100 °C

実験手順

105 g of 2,4-difluorocinnamic acid from Example 5 were dissolved in 450 ml of tetrahydrofuran and reacted with 5 g of palladium on active carbon with stirring at 100° C. and a hydrogen pressure of 50 bar. After a constant pressure had been achieved, the mixture was cooled to room temperature, the pressure was released, the palladium catalyst was filtered off and the solvent was removed by distillation. After drying in vacuo, 104.1 g of 3-(2,4-difluorophenyl)-propionic acid (98% of theory; melting point: 100-102° C.) were obtained.

後処理

  1. temperaturethe mixture was cooled to room temperature
  2. filtrationthe palladium catalyst was filtered off
  3. customthe solvent was removed by distillation
  4. customAfter drying in vacuo

出典と根拠

ORDレコード
ord-a3ee7cc74cbf476d81e3da58a05df9d4
出典データセット
uspto-grants-2008_06
特許番号
US07381832B2

関連ノート

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