Sodium Hydroxide → 3-(2,4-difluorophenyl)propanoic Acid

HRID 130607

反応式

HRID 130607 の反応式
[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[OH-].[Na+].[H][H]>[Pd]>[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 6035023-(2,4-Difluorophenyl)acrylic AcidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 49863953-(2,4-difluorophenyl)propanoic Acid収率 85%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

反応条件

温度
100 °C

実験手順

The procedure was as in Example 5, but the 2,4-difluorocinnamic acid obtained was not isolated. The aqueous-acidic product suspension obtained was rendered alkaline using sodium hydroxide solution and treated with 2 g of Pd/C (5% strength) at 50° C. with further stirring and heated to 100° C. It was then pressurized to 5 bar of hydrogen. After constant pressure had been achieved, it was cooled to room temperature, the pressure was released and the palladium catalyst was filtered off. The alkaline product solution was acidified with sulfuric acid and the product precipitate was isolated by filtration. After drying in vacuo, 95.0 g of 3-(2,4-difluorophenyl)propionic acid (85% of theory) were obtained.

後処理

  1. customwas not isolated
  2. customThe aqueous-acidic product suspension obtained
  3. temperatureit was cooled to room temperature
  4. filtrationthe palladium catalyst was filtered off
  5. customthe product precipitate was isolated by filtration
  6. customAfter drying in vacuo

出典と根拠

ORDレコード
ord-9e4e1d0e34434b238fee93adb46af9bf
出典データセット
uspto-grants-2008_06
特許番号
US07381832B2

関連ノート

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