N,N-Dimethylethylenediamine → N,N-dimethyl-N'-(5-nitropyridin-2-yl)ethane-1,2-diamine

HRID 130663

反応式

HRID 130663 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.C(N=[N+]=[N-])C.[CH3:16][N:17]([CH3:21])[CH2:18][CH2:19][NH2:20]>CC#N>[CH3:16][N:17]([CH3:21])[CH2:18][CH2:19][NH:20][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 66053N,N-DimethylethylenediamineHCID 783082-Chloro-5-nitropyridineHCID 79118Ethane, azido-

生成物 1

HCID 3696952N,N-dimethyl-N'-(5-nitropyridin-2-yl)ethane-1,2-diamine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 2-chloro-5-nitropyridine 106-A and EtN3 (4.7 g, 46.5 mmol) in CH3CN (150 ml) was added N,N-dimethylethlenediamine 106-B (4.1 g, 46.5 mmol). The solution was stirred at room temperature for 3 hours, extracted with EtOAc, washed (brine), dried(MgSO4) and concentrated to give N,N-dimethyl-N′-(5-nitropyridin-2-yl)ethane-1,2-diamine 106-C (5.2 g) as a yellow solid.

後処理

  1. extractionextracted with EtOAc
  2. washwashed (brine), dried(MgSO4)
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-3632a75afb1e4d6bab2873d1474fea9c
出典データセット
uspto-grants-2008_06
特許番号
US07381824B2

関連ノート

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