Hydrochloric Acid → 5-Acetyl-1,3-benzoxazol-2(3H)-one

HRID 132679

反応式

HRID 132679 の反応式
C(N(CC)CC)C.ClC(Cl)(O[C:12](=[O:18])[O:13][C:14](Cl)(Cl)Cl)Cl.[NH2:20][C:21]1[CH:26]=[C:25]([C:27]([CH3:29])=[O:28])[CH:24]=[CH:23]C=1O.Cl>C1COCC1>[CH3:29][C:27]([C:25]1[CH:24]=[CH:23][C:14]2[O:13][C:12](=[O:18])[NH:20][C:21]=2[CH:26]=1)=[O:28]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 94429TriphosgeneHCID 137241423'-Amino-4'-hydroxyacetophenone

生成物 1

HCID 151135715-Acetyl-1,3-benzoxazol-2(3H)-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

7.8 ml of triethylamine and 2.75 g (0.0093 mol) of triphosgene are added to a mixture of 4.2 g (0.0277 mol) of 2-amino-4-methylcarbonylphenol in 100 ml of THF, at 0° C. The mixture is stirred at room temperature for 1 hour, poured into 100 ml of a 0.5N HCl solution and extracted with ethyl acetate, the organic phase is dried and the solvent is evaporated off. The compound of the title is obtained.

後処理

  1. extractionextracted with ethyl acetate
  2. customthe organic phase is dried
  3. customthe solvent is evaporated off
  4. customThe compound of the title is obtained

出典と根拠

ORDレコード
ord-4bcf49dca56c44ff98bc5112ba8c17d6
出典データセット
uspto-grants-2008_06
特許番号
US07388031B2

関連ノート

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