Pyridine → 1,2-butandiol Dibenzoate

反応式

[CH2:1]([OH:6])[CH:2]([OH:5])[CH2:3][CH3:4].[C:7](Cl)(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.N1C=C[CH:19]=[CH:18][CH:17]=1.[O:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>O>[C:7]([O:6][CH2:1][CH:2]([O:5][C:26](=[O:22])[C:25]1[CH:19]=[CH:18][CH:17]=[CH:23][CH:24]=1)[CH2:3][CH3:4])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

実験手順

To the reactor were added 1,2-butylene-glycol (2.5 g), benzoyl chloride (7.8 g), pyridine (8.8 g) and tetrahydrofuran (70 ml). The reactants was mixed and heated refluxing for 4 hours, then cooled to room temperature. Water was added to the reaction system until the inorganic phase was transparent. Organic phase was separated. Inorganic phase was extracted with ethyl ether. The combined organic phase was washed with water, dried over anhydrous sodium sulfate. After concentrated, 3.95 g product was separated. 1H-NMR: δ (ppm)1.0-1.1 (3H), 1.7-1.9(2H), 4.4-4.6(2H), 5.4-5.5(1H) and 7.4-8.2(10H).