8-Methylquinoline → Quinoline, 8-methyl-, 1-oxide

HRID 133099

反応式

HRID 133099 の反応式
ClC1C=CC=C(C(OO)=[O:9])C=1.[CH3:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[N:21]=[CH:20][CH:19]=[CH:18]2>ClCCl>[CH3:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[N+:21]([O-:9])=[CH:20][CH:19]=[CH:18]2

参加物

4

反応物 2

HCID 119108-MethylquinolineHCID 70297m-Chloroperbenzoic acid

生成物 1

HCID 12488418Quinoline, 8-methyl-, 1-oxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 2.45 g of m-chloroperbenzoic acid in 15 ml of dichloromethane is added dropwise to a solution of 1 g of commercially available 8-methylquinoline in 15 ml of dichloromethane. The reaction mixture is stirred over night diluted with 30 ml of dichloremethane and extracted two times each with 50 ml of halfsaturated aqueous sodium hydrogencarbonate solution. The organic layer is dried over magnesium sulfate, filtered and evaporated in vacuo. The residue is chromatographed on silica gel (dichloromethane/methanol 98:2). 1 g of the title compound are obtained as colourless solid.

後処理

  1. additiondiluted with 30 ml of dichloremethane
  2. extractionextracted two times each with 50 ml of halfsaturated aqueous sodium hydrogencarbonate solution
  3. dry with materialThe organic layer is dried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customThe residue is chromatographed on silica gel (dichloromethane/methanol 98:2)

出典と根拠

ORDレコード
ord-ad3c59b8ebdc4483b2bd12794794eebd
出典データセット
uspto-grants-2008_06
特許番号
US07390819B2

関連ノート

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