2-Pyrazinecarboxylic acid → N-(4-benzyloxy-3-fluorophenyl)pyrazinecarboxamide

HRID 13324ノート

反応式

HRID 13324 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([OH:9])=O.Cl.CN(C)CCCN=C=NCC.[CH2:22]([O:29][C:30]1[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][C:31]=1[F:37])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>N1C=CC=CC=1>[CH2:22]([O:29][C:30]1[CH:36]=[CH:35][C:33]([NH:34][C:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)=[O:9])=[CH:32][C:31]=1[F:37])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

参加物

5

反応物 3

HCID 10472-Pyrazinecarboxylic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 219518923-Fluoro-4-phenylmethoxyaniline

生成物 1

HCID 23145734N-(4-benzyloxy-3-fluorophenyl)pyrazinecarboxamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2.59 g of pyrazine-2-carboxylic acid and 4.73 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride were added to a pyridine (60 ml) solution of 4.13 g of 4-benzyloxy-3-fluoroaniline, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and then water was added to it. The resulting deposit was taken out through filtration to obtain the entitled compound as a brown solid.

後処理

  1. customthe reaction liquid
  2. customPyridine was evaporated away under reduced pressure
  3. additionwater was added to it
  4. filtrationThe resulting deposit was taken out through filtration

出典と根拠

ORDレコード
ord-4f8f248a00a74e1a95b45c2060380d81
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

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