Pyridine → 1-(2-(2-(5-bromo-pyridin-2-yl)-6-(4-methanesulfonyl-phenoxy)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone

HRID 13345ノート

反応式

HRID 13345 の反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].N1C=CC=CC=1.[Br:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[NH:25][C:24]3[CH:26]=[C:27]([CH:41]4[CH2:45][CH2:44][CH2:43][NH:42]4)[C:28]([O:30][C:31]4[CH:36]=[CH:35][C:34]([S:37]([CH3:40])(=[O:39])=[O:38])=[CH:33][CH:32]=4)=[CH:29][C:23]=3[N:22]=2)=[N:19][CH:20]=1>C(Cl)(Cl)Cl>[Br:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[NH:25][C:24]3[CH:26]=[C:27]([CH:41]4[CH2:45][CH2:44][CH2:43][N:42]4[C:1](=[O:3])[CH3:2])[C:28]([O:30][C:31]4[CH:36]=[CH:35][C:34]([S:37]([CH3:40])(=[O:38])=[O:39])=[CH:33][CH:32]=4)=[CH:29][C:23]=3[N:22]=2)=[N:19][CH:20]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 231454112-(5-bromo-pyridin-2-yl)-5-(4-methanesulfonyl-phenoxy)-6-pyrrolidin-2-yl-1H-benzimidazole

生成物 1

HCID 112498721-(2-(2-(5-bromo-pyridin-2-yl)-6-(4-methanesulfonyl-phenoxy)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

0.050 ml of acetic anhydride was added to a pyridine (2 ml) solution of 220 mg of 2-(5-bromo-pyridin-2-yl)-5-(4-methanesulfonyl-phenoxy)-6-pyrrolidin-2-yl-1H-benzimidazole, and the reaction liquid was stirred at room temperature for 30 minutes. The reaction liquid was diluted with chloroform, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: chloroform/methanol/aqueous ammonia=50/1/0.1) to obtain the entitled compound as a pale brown solid.

後処理

  1. customthe reaction liquid
  2. customThe reaction liquid
  3. washwashed with water and saturated saline in order
  4. dry with materialdried with anhydrous magnesium sulfate
  5. customThe solvent was evaporated away under reduced pressure
  6. customthe resulting residue was purified through silica gel column chromatography (developing solvent: chloroform/methanol/aqueous ammonia=50/1/0.1)

出典と根拠

ORDレコード
ord-6157a008fecb49d1997f0c1b6314357c
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

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