4-Hydroxybenzoic Acid → 4-Hydroxy-3-iodobenzoic acid (2IPCOOH)

HRID 133705

反応式

HRID 133705 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+].[I-:13].[Na+].Cl[O-].[Na+].OS(O)(=O)=O>O>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[I:13]

参加物

7

反応物 5

HCID 1354-Hydroxybenzoic AcidHCID 1118Sulfuric AcidHCID 5238Sodium IodideHCID 14798Sodium HydroxideHCID 23665760Sodium Hypochlorite

生成物 1

HCID 4494734-Hydroxy-3-iodobenzoic acid (2IPCOOH)

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

30 g of 4-hydroxybenzoic acid are placed in 780 ml of water containing 18 g of sodium hydroxide, 49.5 g of sodium iodide are added, 675 ml of 3.5% sodium hypochlorite solution are run in slowly and the mixture is left with stirring at AT for 13 hours. 60 ml of concentrated H2SO4 are added and then, after cooling, the precipitate formed is filtered off and washed with water. This gives 32.46 g of the expected compound, m.p.=163° C.

後処理

  1. additionare added
  2. waitis left
  3. temperatureafter cooling
  4. customthe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water

出典と根拠

ORDレコード
ord-f4bd56211cd14a3fb5d2d390152a6732
出典データセット
uspto-grants-2008_06
特許番号
US07390924B2

関連ノート

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