Lithium Hydroxide → 3-Hydroxy-3-(4-methoxyphenyl)propanoic acid

HRID 133793

反応式

HRID 133793 の反応式
[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)[CH2:3][C:4]([O:6]CC)=[O:5].[OH-].[Li+]>C1COCC1>[OH:1][CH:2]([C:9]1[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][CH:14]=1)[CH2:3][C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 11096232Ethyl 3-hydroxy-3-(4-methoxyphenyl)propanoate

生成物 1

HCID 149273073-Hydroxy-3-(4-methoxyphenyl)propanoic acid収率 92.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of ethyl 3-hydroxy-3-(4-methoxyphenyl)propanoate (252 mg, 1.1 mmol) in THF (1.1 mL) was added 1 N lithium hydroxide (1.1 mL), and the resulting solution was stirred at room temperature for 3 h. Most of the solvents were removed in vacuo, and 1N hydrochloric acid (1.1 mL) was added. The aqueous layer was extrated with ethyl acetate (x3), and the combined organic layers were dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated in vacuo to give the title compound as an off-white solid (200 mg, 91% yield). 1H NMR (400 MHz, CD3OD) δ 2.57-2.63 (m, 1 H) 2.65-2.72 (m, 1 H) 3.29 (s, 8 H) 3.76 (s, 3 H) 4.82 (s, 9 H) 5.01 (dd, J=8.56, 5.29 Hz, 1 H) 6.86 (ddd, J=9.19, 2.77, 2.39 Hz, 2 H) 7.26-7.30 (m, 2 H). HPLC retention time: 1.392 min (method A). MS (ESI) (M+Na)+ 218.92.

後処理

  1. customMost of the solvents were removed in vacuo, and 1N hydrochloric acid (1.1 mL)
  2. additionwas added
  3. dry with materialthe combined organic layers were dried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customThe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-84c1b332d1df40789a9bc1fdf08ab0ae
出典データセット
uspto-grants-2008_06
特許番号
US07390925B2

関連ノート

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