Methanamine, N-methoxy-, hydrochloride (1:1) → 2-fluoro-N-methoxy-N-methylbenzamide

HRID 13418ノート

反応式

HRID 13418 の反応式
Cl.[CH3:2][O:3][NH:4][CH3:5].Cl.C(N=C=NCCCN(C)C)C.[F:18][C:19]1[CH:27]=[C:26]([N+]([O-])=O)[CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=O>N1C=CC=CC=1>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([N:4]([O:3][CH3:2])[CH3:5])=[O:23]

参加物

5

反応物 3

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 3026792-Fluoro-4-nitrobenzoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

生成物 1

HCID 183575562-fluoro-N-methoxy-N-methylbenzamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5.79 g of N-methoxy-N-methylamine hydrochloride and 12.4 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (80 ml) suspension of 10 g of 2-fluoro-4-nitrobenzoic acid, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and water was added to it. The resulting deposit was taken out through filtration, washed with water, and dried to obtain the entitled compound as a pale yellow solid.

後処理

  1. customthe reaction liquid
  2. customPyridine was evaporated away under reduced pressure, and water
  3. additionwas added to it
  4. filtrationThe resulting deposit was taken out through filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-76d5f9db0bc242af8f1bbe578660f790
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

読み込み中…