4-Bromoaniline → (4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine

HRID 13455

反応式

HRID 13455 の反応式
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1.C(N(C(C)C)CC)(C)C>CN(C)C=O>[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:2]2[O:3][C:4]3[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=3[N:6]=2)=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 78074-BromoanilineHCID 81531DiisopropylethylamineHCID 118197122-Chloro-5-methoxy-1,3-benzoxazole

生成物 1

HCID 22040817(4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318

後処理

  1. concentrationThe resultant mixture was concentrated
  2. custompartitioned between ethyl acetate and water
  3. washThe organic layer was washed with brine
  4. customdried
  5. customPurification on silica gel

出典と根拠

ORDレコード
ord-9bac4797f8dc4d1cae695a5979e23f2d
出典データセット
uspto-grants-2010_06
特許番号
US07728010B2

関連ノート

読み込み中…