4-Bromoaniline → (4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine
反応式
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1.C(N(C(C)C)CC)(C)C>CN(C)C=O>[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:2]2[O:3][C:4]3[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=3[N:6]=2)=[CH:16][CH:15]=1参加物
5
実験手順
The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318
後処理
- concentrationThe resultant mixture was concentrated
- custompartitioned between ethyl acetate and water
- washThe organic layer was washed with brine
- customdried
- customPurification on silica gel
出典と根拠
- ORDレコード
- ord-9bac4797f8dc4d1cae695a5979e23f2d
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728010B2
反応ノート
読み込み中…