Hydrochloric Acid → HCID 178432390、化合物

HRID 1348549ノート

反応式

HRID 1348549 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10](=O)[CH2:11]C(OCC)=O.[ClH:18].[NH2:19][C:20]1[NH:21][CH:22]=[CH:23][N:24]=1.[CH2:25]1CN2C(=NCCC2)C1.Cl.[OH2:35]>C(Cl)(Cl)Cl.CN(C)C=O>[OH:35][C:25]1[N:21]2[CH:22]=[CH:23][N:24]=[C:20]2[N:19]=[C:10]([CH3:11])[C:9]=1[C:3]1[C:4]([F:8])=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:18]

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 962Water2 回HCID 763491,5-Diazabicyclo(4.3.0)non-5-eneHCID 122112381H-Imidazol-2-amine hydrochlorideHCID 63022492Ethyl (2-chloro-6-fluorophenyl)acetoacetate

生成物 1

HCID 178432390HCID 178432390、化合物

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

A mixture of 1.29 g of ethyl (2-chloro-6-fluorophenyl)acetoacetate, 0.60 g of aminoimidazole hydrochloride, 1.24 g of 1,5-diazabicyclo[4.3.0]-5-nonene (DBN) and 5 ml of N,N-dimethylformamide was heated at 100° C. for 14 hours. The reaction mixture was allowed to cool, and chloroform and water were added thereto. To the separated water layer, conc. hydrochloric acid was added and the precipitate was filtered, which was followed to subject to silica gel chromatography to give 0.16 g of 5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine.

後処理

  1. temperatureto cool
  2. filtrationthe precipitate was filtered

出典と根拠

ORDレコード
ord-7054545e715948659e3fcd2f805a7e49
出典データセット
uspto-grants-2007_05
特許番号
US07211545B2

反応ノート

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