Lithium Hydroxide → 2-Hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acid

HRID 1348655ノート

反応式

HRID 1348655 の反応式
C([O:3][C:4](=[O:16])[C:5]([OH:15])([CH3:14])[C:6]([NH:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[O:7])C.[OH-].[Li+]>O1CCCC1.O>[OH:15][C:5]([CH3:14])([C:6]([NH:8][CH2:9][C:10]([F:11])([F:12])[F:13])=[O:7])[C:4]([OH:16])=[O:3]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 86605290HCID 86605290、化合物

生成物 1

HCID 210914072-Hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acid収率 89%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3.680 g (16.0 mmol) (S or R)-2-hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acid ethyl ester, entity B. in 50 ml of tetrahydrofurane were added 0.69 g (16 mmol) of lithium hydroxide in 25 ml of water and the mixture was stirred for 18 hours at room temperature. After removal of the organic solvent by distillation the mixture was acidified to pH 1. Extraction with ethylacetate gave 3.00 g (89%) of the title compound as an oil, MS m/e (%): 213.9 (M−H, 100).

後処理

  1. customAfter removal of the organic solvent
  2. distillationby distillation the mixture
  3. extractionExtraction with ethylacetate

出典と根拠

ORDレコード
ord-aeb78cd11fae4c9984faa0b724c6e36c
出典データセット
uspto-grants-2007_05
特許番号
US07211573B2

反応ノート

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