Sodium Carbonate → HCID 85974475、化合物

反応式

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=O)[CH2:8][CH2:9][CH:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:2]=1.C([O-])([O-])=O.[Na+].[Na+].Cl.[NH2:24][OH:25].C([O-])([O-])=O.[K+].[K+]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=[N:24][OH:25])[CH2:8][CH2:9][CH:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:2]=1

参加物

反応物 4

HCID 10340Sodium Carbonate

HCID 11430Potassium Carbonate

HCID 443297Hydroxyamine hydrochloride

HCID 229922821-(3-Pyridinyl)-3-(tetrahydro-2H-pyran-4-yl)-1-propanone

生成物 1

HCID 85974475HCID 85974475、化合物

実験手順

To 1-(3-pyridyl)-3-(4-oxanyl)propan-1-one (3.00 g, 13.7 mmol) was added saturated aqueous Na2CO3 (25 mL) and hydroxylamine hydrochloride (5.71 g, 82.2 mmol) in small portions. Solid K2CO3 was added to make the solution basic (pH>10). The reaction mixture was stirred overnight at ambient temperature and extracted with chloroform (4×40 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated by rotary evaporation. The resulting colorless viscous liquid (3.00 g, 93.8%) solidified upon standing at ambient temperature.