Ammonium formate → HCID 58860672、化合物
反応式
C([N:8]1[CH2:13][CH2:12][NH:11][C@@H:10]([CH2:14][CH2:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>C(O)C.[OH-].[Pd+2].[OH-]>[C:16]1([CH2:15][CH2:14][C@H:10]2[CH2:9][NH:8][CH2:13][CH2:12][NH:11]2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1参加物
5
実験手順
Dissolve (S)-1-benzyl-3-(2-naphthalen-1-yl-ethyl)-piperazine (1.07 g, 3.03 mmol) in ethanol (10 mL). Add ammonium formate (1.2 g, 19.0 mmol) and palladium hydroxide (200 mg, 20 wt. % on carbon) and heat to reflux. After 7 h, filter the palladium hydroxide and concentrate the filtrate. Combine with Example 422 and purify.
後処理
- filtrationfilter the palladium hydroxide
- concentrationconcentrate the filtrate
- customCombine with Example 422 and purify
出典と根拠
- ORDレコード
- ord-1c716cdefb134ebfb19bcedf67c30c31
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07214673B2
反応ノート
読み込み中…