Water → HCID 21098653、化合物

HRID 1351291ノート

反応式

HRID 1351291 の反応式
[CH3:1][NH:2][S:3]([C:6]1[S:7][C:8]([Br:11])=[CH:9][CH:10]=1)(=[O:5])=[O:4].[H-].[Na+].Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)=[O:17].O>O1CCCC1.C(OCC)(=O)C>[F:24][C:21]1[CH:22]=[CH:23][C:18]([C:16](=[O:17])[CH2:15][N:2]([CH3:1])[S:3]([C:6]2[S:7][C:8]([Br:11])=[CH:9][CH:10]=2)(=[O:4])=[O:5])=[CH:19][CH:20]=1

参加物

7

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 15203645-BroMo-thiophene-2-sulfonic acid M ethylaMide

生成物 1

HCID 21098653HCID 21098653、化合物収率 49.8%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 5-bromothiophene-2-sulfonic acid methyl-amide (608 mg) in tetrahydrofuran (5 mL) was added 60% sodium hydride (115 mg). After stirring for 20 minutes, 2-bromo-1-(4-fluorophenyl)ethanone (630 mg) was added. After adding water and ethyl acetate, and washing the organic layer with saturated sodium chloride water, this solution was dried with anhydrous sodium sulfate. The residue that was obtained upon removing the solvent by evaporation was purified by silica gel column chromatography (hexane/ethyl acetate) and the title compound (464 mg) was obtained as a yellow oily substance.

後処理

  1. washwashing the organic layer with saturated sodium chloride water
  2. dry with materialthis solution was dried with anhydrous sodium sulfate
  3. customThe residue that was obtained
  4. customupon removing the solvent
  5. customby evaporation
  6. customwas purified by silica gel column chromatography (hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-2bb6a6d508844cbfbfc84d6e1733606f
出典データセット
uspto-grants-2007_05
特許番号
US07217723B2

反応ノート

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