Water → HCID 178510798、化合物
反応式
[C:1]1([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:11][OH:12].C(=O)([O-])[O-].[Na+].[Na+].O>CO>[OH:12][NH:11][C:8](=[NH:9])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
6
実験手順
Phenyl acetonitrile (20 g, 170 mmol), hydroxylamine hydrochloride (60 g, 850 mmol) and sodium carbonate (71 g, 850 mmol) were heated under reflux in methanol (300 ml) and water (300 ml) for 5 hours. The reaction mixture was cooled to room temperature, filtered and the filtrate was evaporated and extracted with dichloromethane (3×). The combined organic solutions were washed with water and brine, dried (MgSO4), filtered and concentrated under reduced pressure to give the title compound as a white solid, 15.5 g.
後処理
- filtrationfiltered
- customthe filtrate was evaporated
- extractionextracted with dichloromethane (3×)
- washThe combined organic solutions were washed with water and brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-a24aabb663e940d2b0ae35c01025435c
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07217714B1
反応ノート
読み込み中…