Triethylamine → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline

HRID 13520

反応式

HRID 13520 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CN1C(=O)CCC1.C(N(CC)CC)C.F[C:23]1[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=1>O>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:23]2[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=2)[CH2:4][CH2:3]1

参加物

6

反応物 4

HCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 531671-MethylpiperazineHCID 753995-Fluoro-2-nitroaniline

生成物 1

HCID 27600345-(4-Methylpiperazin-1-yl)-2-nitroaniline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.

後処理

  1. customThe resulting solid was collected
  2. customdried
  3. customutilized without further purification

出典と根拠

ORDレコード
ord-912e0e0b843a42cba63f5551c1645ee6
出典データセット
uspto-grants-2010_06
特許番号
US07728010B2

関連ノート

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