Triethylamine → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CN1C(=O)CCC1.C(N(CC)CC)C.F[C:23]1[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=1>O>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:23]2[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=2)[CH2:4][CH2:3]1参加物
6
実験手順
A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.
後処理
- customThe resulting solid was collected
- customdried
- customutilized without further purification
出典と根拠
- ORDレコード
- ord-912e0e0b843a42cba63f5551c1645ee6
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728010B2
反応ノート
読み込み中…