Acrylonitrile → HCID 68644380、化合物

HRID 1352470ノート

反応式

HRID 1352470 の反応式
Cl.[OH:2][CH2:3][C@@H:4]1[NH:8][CH2:7][C@@H:6]([OH:9])[CH2:5]1.[C:10](#[N:13])[CH:11]=[CH2:12]>C(=O)([O-])[O-].[K+].[K+].C(#N)C>[OH:9][C@@H:6]1[CH2:7][N:8]([CH2:12][CH2:11][C:10]#[N:13])[C@@H:4]([CH2:3][OH:2])[CH2:5]1

参加物

5

反応物 2

HCID 7855AcrylonitrileHCID 68644206(3S,5R)-5-(HYDROXYMETHYL)PYRROLIDIN-3-OL HCL

生成物 1

HCID 68644380HCID 68644380、化合物

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 11430Potassium Carbonate溶媒

実験手順

(3S,5R)-5-Hydroxymethylpyrrolidin-3-ol hydrochloride (0.4 g) described in Biochemistry, Vol. 5, pp. 1154–1155 (1966) was dissolved in aqueous potassium carbonate solution (2 mL) and acetonitrile (2 mL). Acrylonitrile (0.5 mL) was added and the mixture was stirred at room temperature for 5 hr. After the completion of the reaction, the reaction mixture was concentrated and the obtained residue was suspended in chloroform-methanol and dried by adding magnesium sulfate. Magnesium sulfate was filtered off and the solvent was concentrated to give 3-[(2R,4S)-4-hydroxy-2-hydroxymethylpyrrolidin-1-yl]propionitrile (0.47 g).

後処理

  1. customAfter the completion of the reaction
  2. concentrationthe reaction mixture was concentrated
  3. customdried
  4. additionby adding magnesium sulfate
  5. filtrationMagnesium sulfate was filtered off
  6. concentrationthe solvent was concentrated

出典と根拠

ORDレコード
ord-2244a8fe2aae448c800eb04f3cc90039
出典データセット
uspto-grants-2007_05
特許番号
US07220759B2

反応ノート

読み込み中…