Aniline → N-phenylquinolin-4-amine
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>[OH-].[Na+]>[C:13]1([NH:12][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
4
反応条件
- 温度
- 150 °C
実験手順
A mixture of 4-chloroquinoline (10 g) and aniline (11.4 g) was warmed to 150° C. for 30 min. A solution of sodium hydroxide 1 N (200 ml) was added. After extraction with ethyl acetate (1 L), the organic layer was separated and dried over sodium sulfate. The solvent was removed to afford an amorphous materiel, which was crystallized in cyclohexane. Phenyl-quinolin-4-yl-amine (13.7 g) was obtained after filtration.
後処理
- extractionAfter extraction with ethyl acetate (1 L)
- customthe organic layer was separated
- dry with materialdried over sodium sulfate
- customThe solvent was removed
- customto afford an amorphous materiel, which
- customwas crystallized in cyclohexane
出典と根拠
- ORDレコード
- ord-bc16656bbf82477d8617d02915ddd810
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07220760B2
反応ノート
読み込み中…