4-Chloroquinoline → 681828-34-2

HRID 1352504ノート

反応式

HRID 1352504 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>[OH-].[Na+]>[CH:12]1([NH:15][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH2:14][CH2:13]1

参加物

4

反応物 2

HCID 691404-ChloroquinolineHCID 69828Cyclopropylamine

生成物 1

HCID 22935736681828-34-2収率 42.2%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
180 °C

実験手順

A mixture of 4-chloroquinoline (13.9 g) and cyclopropyl amine (9.7 g) was heated at 180° C. under stirring for 16 hours. After cooling, a solution of sodium hydroxide 1N (200 ml) was added. After extraction with dichloromethane (200 ml), the organic layer was separated and dried over sodium sulfate. The solvent was removed under reduce pressure to afford an oil, which was crystallized in acetonitrile (50 ml). Cyclopropyl-quinolin-4-yl-amine (6.6 g; 42% yield) was obtained after filtration.

後処理

  1. temperatureAfter cooling
  2. extractionAfter extraction with dichloromethane (200 ml)
  3. customthe organic layer was separated
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed
  6. customto afford an oil, which
  7. customwas crystallized in acetonitrile (50 ml)

出典と根拠

ORDレコード
ord-101b4c391dc143f3a370737c41a1a6b8
出典データセット
uspto-grants-2007_05
特許番号
US07220760B2

反応ノート

読み込み中…