Sodium Hydroxide → 4-(5,6-dichloro-1H-benzimidazol-2-yl)benzoic acid

HRID 1352656ノート

反応式

HRID 1352656 の反応式
[Cl:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([O:17]C)=[O:16])=[CH:11][CH:10]=3)[NH:8][C:4]=2[CH:3]=1.[OH-].[Na+]>C1COCC1>[Cl:21][C:20]1[C:2]([Cl:1])=[CH:3][C:4]2[N:8]=[C:7]([C:9]3[CH:10]=[CH:11][C:12]([C:15]([OH:17])=[O:16])=[CH:13][CH:14]=3)[NH:6][C:5]=2[CH:19]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 21101171HCID 21101171、化合物

生成物 1

HCID 40731194-(5,6-dichloro-1H-benzimidazol-2-yl)benzoic acid収率 91.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

A mixture of 5,6-dichloro-2-(4-methoxycarbonylphenyl)benzimidazole (2.4 g, 7.47 mmol), prepared as described in Preparation 7, 20% NaOH (7.5 ml, 37.5 mmol) in THF (25 ml) was heated at 50° C. for 1 h. After cooling at room temperature, solvent was removed under reduced pressure and pH was adjusted to 5 with acetic acid. The solid that was precipitated was filtered and dried at 50° C. to give 2.1 g of the title compound (yield 91.8%) as a brown solid, mp>250° C.

後処理

  1. customprepared
  2. temperatureAfter cooling at room temperature
  3. customsolvent was removed under reduced pressure and pH
  4. customThe solid that was precipitated
  5. filtrationwas filtered
  6. customdried at 50° C.

出典と根拠

ORDレコード
ord-7223f598e4994bda884043da906bdf42
出典データセット
uspto-grants-2007_05
特許番号
US07220769B2

反応ノート

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