Tetrahydrofuran → 4-Formylbenzoyl chloride

HRID 13534

反応式

HRID 13534 の反応式
[C:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1)(O)=[O:2].O1CCCC1.C(Cl)(=O)C([Cl:20])=O>>[CH:8]([C:7]1[CH:10]=[CH:11][C:4]([C:1]([Cl:20])=[O:2])=[CH:5][CH:6]=1)=[O:9]

参加物

4

反応物 3

HCID 8028TetrahydrofuranHCID 120884-Formylbenzoic acidHCID 65578Oxalyl chloride

生成物 1

HCID 124246204-Formylbenzoyl chloride

反応条件

温度
2.5 °C

実験手順

To a thin suspension of 4-carboxybenzaldehyde (600 g, 3.92 mol) in tetrahydrofuran (2664 g, 36.57 mol) was added dimethylformadehyde (11.48 g, 0.16 mol) and the reaction mixture was cooled to 0-5° C. with an ice bath. The reaction mixture was then stirred at 0° C. while oxalyl chloride (608.69 g, 4.70 mol) was added slowly. The reaction mixture was stirred until it was deemed complete by 1HNMR to yield the title compound. The reaction mixture was used in the next step without further manipulation.

後処理

  1. additionwas added dimethylformadehyde (11.48 g, 0.16 mol)
  2. additionwas added slowly

出典と根拠

ORDレコード
ord-11c8be357cc7419c80cf8a2b182ca001
出典データセット
uspto-grants-2010_06
特許番号
US07728129B2

関連ノート

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