[H-].[Na+].[CH:3]1([CH:8]([OH:10])[CH3:9])[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl[C:12]1[CH:17]=[C:16](Cl)[N:15]=[CH:14][N:13]=1.[CH2:19]([OH:23])[C:20]#[C:21][CH3:22].[Cl-].[NH4+]>O1CCCC1>[CH2:19]([O:23][C:12]1[CH:17]=[C:16]([O:10][CH:8]([CH:3]2[CH2:7][CH2:6][CH2:5][CH2:4]2)[CH3:9])[N:15]=[CH:14][N:13]=1)[C:20]#[C:21][CH3:22]
In 4 ml of tetrahydrofuran was suspended 0.10 g of sodium hydride (60% in oil), to which 0.4 ml of a solution containing 0.23 g of 1-cyclopentylethanol was added dropwise at 0° C., followed by stirring for 10 minutes. To this was added dropwise 0.4 ml of a solution containing 0.30 g of 4,6-dichloropyrimidine in tetrahydrofuran, followed by stirring at the same temperature for 4 hours. To this was added dropwise 0.4 ml of a solution containing 0.16 g of 2-butyn-1-ol in tetrahydrofuran and further added 0.10 g of sodium hydride (60% in oil), followed by stirring for 3 hours. The reaction mixture was then poured into a saturated aqueous ammonium chloride solution, which was extracted three times with t-butyl methyl ether. The combined organic layers were washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated. The residue was subjected to silica gel column chromatography to give 0.25 g of 4-(2-butynyloxy)-6-(1-cyclopentylethyloxy)pyrimidine (the present, compound (26)).
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