Pyridine → HCID 21105039、化合物

HRID 1354264ノート

反応式

HRID 1354264 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([C:17](Cl)=[O:18])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=1.N1C=CC=CC=1>C(#N)C>[N:24]1[CH:25]=[CH:26][C:21]([NH:20][C:17]([C:11]2[CH:10]=[N:9][N:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[C:12]=2[C:13]([F:16])([F:15])[F:14])=[O:18])=[CH:22][CH:23]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 17274-AminopyridineHCID 27366451-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride

生成物 1

HCID 21105039HCID 21105039、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

1-(4-Chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl chloride (0.100 g, 0.324 mmol) was added to a solution of 4-aminopyridine (0.036 g, 0.387 mmol) and pyridine (0.078 mL, 0.969 mmol) in acetonitrile (10 mL). The reaction mixture was heated at 60° C. for 12 h, concentrated and the crude product was purified by column chromatography on silica gel to give 1-(4-chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid pyridine-4-ylamide. LCMS m/z=366.9 (M+H)+.

後処理

  1. concentrationconcentrated
  2. customthe crude product was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-7f3dcd5f3b364c85b4ab1db73b438cf5
出典データセット
uspto-grants-2007_05
特許番号
US07223782B2

反応ノート

読み込み中…