Water → 4-(1-Propoxyethyl)benzoic acid

HRID 1354794

反応式

HRID 1354794 の反応式
[OH:1][CH:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10]C)=[O:9])=[CH:6][CH:5]=1)[CH3:3].[CH2:14](I)[CH2:15][CH3:16].[H-].[Na+].O>CN(C=O)C>[CH2:14]([O:1][CH:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)[CH3:3])[CH2:15][CH3:16]

参加物

6

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 586417Methyl 4-(1-hydroxyethyl)benzoate

生成物 1

HCID 144734334-(1-Propoxyethyl)benzoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Methyl 4-(1-hydroxyethyl)benzoate (2.0 g) dissolved in DMF (30 ml) was mixed with propyl iodide (3.8 g), and then sodium hydride (50% in oil, 0.53 g) was added. After the end of the exothermic reaction, the mixture was stirred for 1 hour and then water was cautiously added. It was extracted with ethyl acetate, and the organic phase was dried over sodium sulfate, filtered and concentrated. The residue was hydrolyzed by method P-a. This resulted in the product with the molecular weight of 208.26 (C12H16O3); MS (ESI): 209 (M+H+).

後処理

  1. customAfter the end of the exothermic reaction
  2. extractionIt was extracted with ethyl acetate
  3. dry with materialthe organic phase was dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThis resulted in the product with the molecular weight of 208.26 (C12H16O3)

出典と根拠

ORDレコード
ord-26726afcdd094cd9880a8a290125792b
出典データセット
uspto-grants-2007_05
特許番号
US07223788B2

関連ノート

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