4-Hydroxybenzaldehyde → HCID 157607、化合物
反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[NH:10]1[CH2:16][C:14](=[O:15])[NH:13][C:11]1=[O:12].N1CCCCC1.Cl>O>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[C:16]2[NH:10][C:11](=[O:12])[NH:13][C:14]2=[O:15])=[CH:4][CH:3]=1参加物
6
反応条件
- 温度
- 130 °C
実験手順
A mixture of 4-hydroxybenzaldehyde (100 g, 0.819 M), hydantoin (90 g, 0.9 M) and piperidine (165 ml) was heated to 130° C. for 1 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was cooled to 60° C. and 3.21 water was added. The reaction mixture was acidified with 12N HCl. The precipitated solid was filtered and washed with cold water to yield the title compound of the formula (18) (147 g, 88%), (Org. Syn. Vol. V., pp627).
後処理
- customAfter completion of the reaction
- temperaturethe reaction mixture was cooled to 60° C.
- filtrationThe precipitated solid was filtered
- washwashed with cold water
出典と根拠
- ORDレコード
- ord-659085e64d1a48429e9482e3b19c42e1
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07223881B2
反応ノート
読み込み中…