2-Aminopyridine → 6-amino-3-Pyridinepropanol

HRID 1355501ノート

反応式

HRID 1355501 の反応式
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][OH:11])=[CH:4][CH:3]=1.NC1C=CC=CN=1>CCO.[OH-].[OH-].[Pd+2]>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 104392-AminopyridineHCID 185068563-(6-Aminopyridin-3-yl)prop-2-yn-1-ol

生成物 1

HCID 185068066-amino-3-Pyridinepropanol

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

3-(6-Amino-pyridin-3-yl)-prop-2-yn-1-ol (7-2), 2.73 g (18.4 mmol) and Pd(OH)2 (0.27 g) were stirred in 30 mL EtOH (aminopyridine does not completely dissolve). Reaction was put under one atmosphere of H2 for 24 h. The reaction was filtered through a plug of celite, washed with EtOH, and concnetrated to afford the titled compound as an orange oil. 1H NMR (CDCl3) δ 7.90 (d, 1H, J=2.3 Hz), 7.31 (dd, 1H, J=2.4, 8.6 Hz), 6.43 (d, 1H, J=8.7 Hz), 4.38 (bs, 2H), 3.63 (t, 2H, J=7.5 Hz), 2.58 (t, 2H, J=7.2 Hz), 1.97 (bs, 1H), 1.82 (m, 2H).

後処理

  1. dissolutiondoes not completely dissolve)
  2. customReaction
  3. filtrationThe reaction was filtered through a plug of celite
  4. washwashed with EtOH

出典と根拠

ORDレコード
ord-fb35f63d604048f59a6f86e25bd95bff
出典データセット
uspto-grants-2003_07
特許番号
US06586424B2

反応ノート

読み込み中…