Tetrahydrofuran → 6-(4-Biphenylylmethoxy)nicotinic Acid

HRID 1356447ノート

反応式

HRID 1356447 の反応式
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][N:10]=2)=[CH:3][CH:2]=1.C1COCC1>CO.[OH-].[Na+].Cl>[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[CH:3][CH:2]=1

参加物

6

反応物 2

HCID 8028TetrahydrofuranHCID 18508353Methyl 6-(4-biphenylylmethoxy)nicotinate

生成物 1

HCID 178174806-(4-Biphenylylmethoxy)nicotinic Acid収率 83.7%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a solution of methyl 6-(4-biphenylylmethoxy)nicotinate (2.0 g) in methanol (20 ml)/THF(40 ml) was added iN aqueous sodium hydroxide (13 ml) at room temperature. After stirring at room temperature for 4 hr the reaction mixture was diluted with 1 N hydrochloric acid (13 ml) and concentrated. The precipitate was collected by filtration and washed with water and diethyl ether sequentially to obtain the titled compound (1.6 g) as amorphous powder.

後処理

  1. concentrationconcentrated
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and diethyl ether sequentially

出典と根拠

ORDレコード
ord-dfbdd527ca69446aba9847ef571372c9
出典データセット
uspto-grants-2003_07
特許番号
US06586475B1

反応ノート

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