Methyl iodide → HCID 178504149、化合物

HRID 1356518ノート

反応式

HRID 1356518 の反応式
[NH2:1][C:2]([NH:4][C:5]([NH2:7])=[S:6])=[S:3].[I:8][CH3:9]>C1COCC1.C1(C)C=CC=CC=1>[IH:8].[CH3:9][SH:3]=[C:2]([NH:4][C:5]([NH2:7])=[S:6])[NH2:1]

参加物

5

反応物 2

HCID 6328Methyl iodideHCID 2758725Dithiobiuret

生成物 1

HCID 178504149HCID 178504149、化合物収率 85%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirring solution of dithiobiuret (5.0 g, 37 mmol) in THF (75 mL) was added iodomethane (13.1 g, 92.5 mmol, 5.76 ml). After stirring at room temperature for 22 h, the solution was diluted with 150 mL of toluene and allowed to stand at 0° C. for 3 h. The crystals were collected by filtration and washed with cold 2:1 toluene/THF, then dried in vacuo to give the title compound as a white solid (8.7 g, 85%). MS(ESI): 149.9 (M+H)+.

後処理

  1. waitto stand at 0° C. for 3 h
  2. filtrationThe crystals were collected by filtration
  3. washwashed with cold 2:1 toluene/THF
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-b69987d09a7a4ffda9645cb87b3a9d43
出典データセット
uspto-grants-2003_07
特許番号
US06586466B2

反応ノート

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