Water → n-(4-Cyanophenyl)-4-methylbenzenesulfonamide

HRID 1356664ノート

反応式

HRID 1356664 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[C:10]1([CH3:20])[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1.O>N1C=CC=CC=1.C(#N)C>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][S:16]([C:13]2[CH:14]=[CH:15][C:10]([CH3:20])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[CH:3][CH:4]=1)#[N:7]

参加物

6

反応物 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 133964-Aminobenzonitrile

生成物 1

HCID 257975n-(4-Cyanophenyl)-4-methylbenzenesulfonamide収率 98%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6342Acetonitrile溶媒

実験手順

4-Aminobenzonitrile (98%, 500.0 g (4.15 mol) was dissolved in a mixed solvent of pyridine (360 ml) and acetonitrile (900 ml). To this, p-toluenesulfonyl chloride (872.3 g (4.44 mol)) was added with stirring at room temperature. After stirring for 16 hours at room temperature, water (4000 ml) was added to the reaction mixture to bring about separation of crystals. The crystals were filtered and washed with water to give 1153 g (98%) of 4′-cyano-p-toluenesulfonanilide as pale red crude crystals.

後処理

  1. stirringAfter stirring for 16 hours at room temperature
  2. customto bring about separation of crystals
  3. filtrationThe crystals were filtered
  4. washwashed with water

出典と根拠

ORDレコード
ord-fe1a1a27fabb4a81bff7de403bc264c5
出典データセット
uspto-grants-2003_07
特許番号
US06586617B1

反応ノート

読み込み中…