Acetamide, N-ethyl-N-(4-nitrophenyl)- → Acetamide, N-(4-aminophenyl)-N-ethyl-

HRID 1356995ノート

反応式

HRID 1356995 の反応式
[C:1]([N:4]([CH2:14][CH3:15])[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]>C1COCC1.[Pd]>[C:1]([N:4]([CH2:14][CH3:15])[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 74583Acetamide, N-ethyl-N-(4-nitrophenyl)-

生成物 1

HCID 74921Acetamide, N-(4-aminophenyl)-N-ethyl-

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

N-acetyl-N-ethyl-4-nitroaniline (9a) (1.8 g, 8.64 mmol) is hydrogenated in THF (30 ml), over 10%Pd on carbon (100 mg) for 1.5 hours. The catalyst is removed by filtration and the solvent removed evaporation. The product crystalises on standing in hexane, and following filtration, is dried under vacuum; ES+ (M+1) 178.88.

後処理

  1. customfor 1.5 hours
  2. customThe catalyst is removed by filtration
  3. customthe solvent removed
  4. customevaporation
  5. customThe product crystalises
  6. filtrationfiltration
  7. customis dried under vacuum

出典と根拠

ORDレコード
ord-e61e8923ca8d4396b3db6ca9e2d5bab2
出典データセット
uspto-grants-2003_07
特許番号
US06589950B1

反応ノート

読み込み中…