4-Methyl-3-nitrobenzyl alcohol → (3-Amino-4-methylphenyl)methanol

HRID 1357746

反応式

HRID 1357746 の反応式
[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[N+:10]([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:10][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:2]=1[CH3:1])[CH2:6][OH:7]

参加物

5

反応物 2

HCID 1234974-Methyl-3-nitrobenzyl alcoholHCID 178418361HCID 178418361、化合物

生成物 1

HCID 586243(3-Amino-4-methylphenyl)methanol収率 94.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

4-Methyl-3-nitro benzylalcohol (9.7 g, 58 mmol) in ethanol (200 mL) was reduced under 4 atmospheres of hydrogen gas for 4 hours in the presence of 10% Pd/C (0.5 g) to yield after a standard workup 7.54 g (93%) of the title compound.

出典と根拠

ORDレコード
ord-83dda6c0962d4d169663d0f091c17d1b
出典データセット
uspto-grants-2003_07
特許番号
US06593335B1

関連ノート

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