Chloroacetonitrile → 2-(4-Hydroxypiperidin-1-YL)acetonitrile
反応式
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.Cl[CH2:9][C:10]#[N:11].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:9][C:10]#[N:11])[CH2:4][CH2:3]1参加物
5
実験手順
A mixture of 4-hydroxypyridine (4.04 g, 40 mmol), chloroacetonitrile (2.78 mL, 44 mmol) and potassium carbonate (22 g, 160 mmol) in acetonitrile (50 mL) was stirred at rt for overnight. The insolubles were filtered off, the filtrate was concentrated to give 5.6 g of (4-hydroxy-piperidin-1-yl)-acetonitrile.
後処理
- filtrationThe insolubles were filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-9b2ecec2ff064a87b51db3bf718a57b7
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06599902B2
反応ノート
読み込み中…