3-Aminoazetidine, 3-BOC protected → tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate

HRID 136

反応式

HRID 136 の反応式
CC(C)(C)OC(=O)NC1CNC1.COc1cc(Br)ccn1>CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>COc1cc(N2CC(NC(=O)OC(C)(C)C)C2)ccn1

参加物

7

反応物 2

HCID 15194053-Aminoazetidine, 3-BOC protectedHCID 140623094-Bromo-2-methoxypyridine

生成物 1

HCID 118055029tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate収率 100.28%

試薬・触媒・溶媒 4

HCID 23676156Sodium t-butoxide試薬HCID 634876Binap, (A+-)-触媒HCID 9811564Bis(dibenzylideneacetone)palladium触媒HCID 1140Toluene溶媒

反応条件

温度
70 °C

実験手順

A mixture of all the reactants in toluene was heated in a sealed vial at 70 °C overnight. According to LC-MS the reaction was completed and the product had been formed. Toluene was removed, water was added and the product was extracted with DCM. The organic phase was dried through phase separator and concentrated. The crude was used without further purification in the next step, EN01762-02.

出典と根拠

ORDレコード
ord-3870c5bc1f6548e38bd05a0e29b91f59
出典データセット
750 AstraZeneca ELN dataset
元リンク
出典を表示

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