Sodium hydride → Ethyl 2-[3-(4-methoxyphenyl)prop-2-en-1-ylidene]-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate

HRID 1360205ノート

反応式

HRID 1360205 の反応式
[H-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8](/[CH:11]=[CH:12]/[CH:13]=O)=[CH:7][CH:6]=1.C(OP([CH:23]1[C:28](=[O:29])[NH:27][C:26]2[CH:30]=[C:31]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH:32]=[CH:33][C:25]=2[S:24]1)(OCC)=O)C>C1COCC1>[CH3:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH:11]=[CH:12][CH:13]=[C:23]2[C:28](=[O:29])[NH:27][C:26]3[CH:30]=[C:31]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH:32]=[CH:33][C:25]=3[S:24]2)=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 641294p-METHOXYCINNAMALDEHYDEHCID 23157962ethyl 2-(diethoxyphosphoryl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate

生成物 1

HCID 86618897Ethyl 2-[3-(4-methoxyphenyl)prop-2-en-1-ylidene]-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Under ice-cooling, sodium hydride (4.65 g, content 60%) was added in small portions to a THF solution (300 ml) containing (2E)-3-(4-methoxyphenyl)acrylaldehyde (10 g) synthesized by the process described in Reference Example 1 and ethyl 2-(diethoxyphosphoryl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate (21.7 g, synthesized according to the process disclosed in WO00/63197). The resulting mixture was slowly warmed up to room temperature and stirred overnight. The same aldehyde as above (1.5 g) was added thereto and stirred for another 2 hours. The resulting mixture was concentrated under reduced pressure, and ethyl acetate (30 ml), hexane (100 ml), a 1N aqueous hydrochloric acid solution (50 ml) and water (600 ml) were added to the residue, followed by stirring at room temperature for 6 hours. The solid was collected by filtration and dried under reduced pressure. Ethyl 2-[3-(4-methoxyphenyl)prop-2-en-1-ylidene]-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate (22.43 g) was obtained as a yellow solid.

後処理

  1. temperatureUnder ice-cooling
  2. customsynthesized by the process
  3. customsynthesized
  4. stirringstirred for another 2 hours
  5. concentrationThe resulting mixture was concentrated under reduced pressure, and ethyl acetate (30 ml), hexane (100 ml)
  6. additiona 1N aqueous hydrochloric acid solution (50 ml) and water (600 ml) were added to the residue
  7. stirringby stirring at room temperature for 6 hours
  8. filtrationThe solid was collected by filtration
  9. customdried under reduced pressure

出典と根拠

ORDレコード
ord-b25efe48dcf248d7bd64a56d159b4677
出典データセット
uspto-grants-2011_02
特許番号
US07879843B2

反応ノート

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