N-bromobutanimide → N-[5-(2-Bromo-thiophen-3-yl)-4-methyl-thiazol-2-yl]-acetamide
反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH:12][C:13](=[O:15])[CH3:14])[S:5][C:6]=1[C:7]1[CH:11]=[CH:10][S:9][CH:8]=1.[Br:16]N1C(=O)CCC1=O>C(#N)C>[Br:16][C:8]1[S:9][CH:10]=[CH:11][C:7]=1[C:6]1[S:5][C:4]([NH:12][C:13](=[O:15])[CH3:14])=[N:3][C:2]=1[CH3:1]参加物
4
実験手順
N-[4-methyl-5-(3-thienyl)-1,3-thiazol-2-yl]acetamide obtained in Step I as described above (3880 mg; 16.3 mmol; 1 eq) is dissolved in ACN (375 ml). N-bromosuccinimide (2898 mg; 16.3 mmol; 1 eq) is added and the resulting solution is stirred at room temperature for 30 minutes. Solvents are concentrated. Water is added and the desired product is extracted with EtOAc (3 times). Organic phases are washed with water (3 times) and dried over MgSO4, affording the title compound (5000 mg; 97%).
後処理
- concentrationSolvents are concentrated
- additionWater is added
- extractionthe desired product is extracted with EtOAc (3 times)
- washOrganic phases are washed with water (3 times)
- dry with materialdried over MgSO4
出典と根拠
- ORDレコード
- ord-4cc5c5d4d6264d5fbcc18c1d7c84900b
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07879888B2
反応ノート
読み込み中…