Sodium Iodide → Propanoic acid, 2-methyl-, 1-iodoethyl ester
反応式
[I-:1].[Na+].Cl[CH:4]([O:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9])[CH3:5]>CC#N>[I:1][CH:4]([O:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9])[CH3:5]参加物
4
実験手順
Sodium iodide (4.5 g, 29.43 mmol) was dissolved in CH3CN (13 mL). Compound 13 (2.16 g, 14.4 mmol) and CH3CN (5 mL) were added and stirred for 6.5 hours. After filtering and concentrating, the reaction solution was diluted with ether (10 mL) and then re-concentrated to give 1.597 g of isobutyric acid 1-iodo-ethyl ester 14 (Yield: 46%). 1HNMR (CDCl3, 500 MHz) δ1.16-1.21 (m, 6H), 2.20 (d, J=5.5 Hz, 3H), 2.45-2.61 (m, 1H), 6.86 (q, J=6.0 Hz, 1H).
後処理
- filtrationAfter filtering
- concentrationconcentrating
- additionthe reaction solution was diluted with ether (10 mL)
- concentrationre-concentrated
出典と根拠
- ORDレコード
- ord-ee64fc1c732b4f81b3a46c6f24c5c055
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07879906B2
反応ノート
読み込み中…