Acetic Acid → Ethyl 2-bromo-4,5,7,8-tetrahydro-6H-thieno[2,3-d]azepine-6-carboxylate
反応式
[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH2:11][C:10]2[CH:13]=[CH:14][S:15][C:9]=2[CH2:8][CH2:7]1)=[O:5])[CH3:2].CC(O)=O.C1C(=O)N([Br:27])C(=O)C1>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH2:11][C:10]2[CH:13]=[C:14]([Br:27])[S:15][C:9]=2[CH2:8][CH2:7]1)=[O:5])[CH3:2]参加物
5
実験手順
The product of Example 1, step (d) (80 mg, 0.35 mmol) was dissolved in 2 mL of 1:1 CHCl3:HOAc and treated with NBS (62 mg, 0.35 mmol). After 15 minutes, the reaction was concentrated to dryness, dissolved in a minimal amount of EtOAc and filtered through a pad of silica gel. The filtrate was evaporated to give 105 mg of the sub-title compound.
後処理
- concentrationthe reaction was concentrated to dryness
- dissolutiondissolved in a minimal amount of EtOAc
- filtrationfiltered through a pad of silica gel
- customThe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-86162a64c6694d4d9a4beaa034e9ba82
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07893051B2
反応ノート
読み込み中…