Borane → HCID 66940734、化合物

温度

65 °C

To a solution of rac-(3S,4R)-1-benzyl-4-(4-fluoro-2-methyl-phenyl)-pyrrolidin-3-ylamine (130 mg, 0.46 mmol) in THF (6 ml) was added a solution of K2CO3 (126 mg, 0.91 mmol) in H2O (2 ml). After 10 minutes, ethyl chloroformate (0.05 ml, 0.48 mmol) was added and stirring was continued at RT for an additional 2 h. The intermediate carbamate was then extracted with Et2O, dried over Na2SO4 and concentrated under vacuo to give viscous oil. The oil was taken up in THF (5 ml) and a solution of borane in THF (1M) was added (1.9 ml). The reaction mixture was then heated at 65° C. over night, cooled to RT and carefully quenched with conc. HCl (2 ml). The mixture was then heated at 80° C. for 2 h, cooled to RT, concentrated under vacuo, diluted with Et2O (30 ml) and neutralized with an aqueous solution of NaHCO3. The organic phases were dried over Na2SO4 and the product purified by flash chromatography (SiO2, CH2Cl2/MeOH 9:1) to afford 77 mg (56%) of rac-[(3S,4R)-1-benzyl-4-(4-fluoro-2-methyl-phenyl)-pyrrolidin-3-yl]-methyl-amine as a colorless oil. ES-MS m/e: 299.3 (M+H+).

1. waitwas continued at RT for an additional 2 h
2. extractionThe intermediate carbamate was then extracted with Et2O
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under vacuo
5. customto give viscous oil
6. temperaturecooled to RT
7. customcarefully quenched with conc. HCl (2 ml)
8. temperatureThe mixture was then heated at 80° C. for 2 h
9. temperaturecooled to RT
10. concentrationconcentrated under vacuo
11. additiondiluted with Et2O (30 ml)
12. dry with materialThe organic phases were dried over Na2SO4
13. customthe product purified by flash chromatography (SiO2, CH2Cl2/MeOH 9:1)

ORDレコード

ord-0dc0433cd0e847e9a7dfec7a32879b7a

出典データセット

uspto-grants-2011_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07893062B2