HCID 23513713、化合物 → HCID 23513707、化合物

HRID 1366357ノート

反応式

HRID 1366357 の反応式
[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:26]=[CH:25][C:8]([C:9]([CH:11]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[N+:21]([O-])=O)[C:12]2=[O:24])=[O:10])=[CH:7][CH:6]=1>C1COCC1.[Pd]>[NH2:21][C:17]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:18]=1[C:19](=[O:20])[CH:11]([C:9](=[O:10])[C:8]1[CH:25]=[CH:26][C:5]([O:4][CH2:3][CH2:2][Cl:1])=[CH:6][CH:7]=1)[C:12]2=[O:24]

参加物

4

反応物 1

HCID 23513713HCID 23513713、化合物

生成物 1

HCID 23513707HCID 23513707、化合物収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of 2-[4-(2-chloroethoxy)benzoyl]-4-nitroindan-1,3-dione (27 g, 72 mmol) in THF (1200 mL) under argon was added 10% Pd/C (2 g, 1.9 mmol). The argon was evacuated and replaced by a balloon of H2. The reaction was stirred overnight and the catalyst removed by filtration. The solvent was evaporated under reduced pressure to give the desired aniline as a yellow solid (24 g, 98% yield).

後処理

  1. customThe argon was evacuated
  2. customthe catalyst removed by filtration
  3. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-63b29fb3af4c4c699d1b3369e62f5713
出典データセット
uspto-grants-2011_02
特許番号
US07893057B2

反応ノート

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