Hydrochloric Acid → HCID 66973439、化合物
反応式
[O:1]=[C:2]1[CH2:7][O:6][C@H:5]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[C@H:4]2[N:3]1[CH2:15][C:16]([O:18]CC)=[O:17].[Li+].[OH-].Cl>C1COCC1.O>[O:1]=[C:2]1[CH2:7][O:6][C@H:5]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[C@H:4]2[N:3]1[CH2:15][C:16]([OH:18])=[O:17]参加物
6
実験手順
To a solution of ethyl [(4aR,9aS)-3-oxo-2,3,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-4(4aH)-yl]acetate from Step C (480 mg, 1.74 mmol) in THF (7.5 mL) and H2O (2.5 mL) was added 1 N aqueous LiOH (2.1 mL, 2.09 mmol) and the resulting mixture was stirred at ambient temperature for 4 h. The mixture was adjusted to pH 4 by addition of 1 N HCl and concentrated to dryness in vacuo to give the title compound. MS: m/z=248 (M+1).
後処理
- concentrationconcentrated to dryness in vacuo
出典と根拠
- ORDレコード
- ord-aa98e07d066e4ac994d22474d75036d1
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07893079B2
反応ノート
読み込み中…